I like it. I can only think of two slight drawbacks.
First, we tend to use it more frquently in cases where the "fault" or agency resides outside of ourselves. What is troublesome is the cause or circumstance which gives rise to the trouble, rather than our response to it. "A troublesome wasp" or "A troublesome customer", for example. This would make further exploration into our contribution to the trouble a bit harder.
Second, as an adjective, it would need to be prefixed with "the" in order to make sense in some formulations. "The Noble Truth of The Troublesome", for example. "The Noble Truth of Trouble" has a touch of the bathetic. "Suffering" doubles as a noun or an adjective according to context, and "Stress" just needs "-full".